Natural Herpes Cure that is Safe and Effective is Now Available from Resolve Herpes

LOS ANGELES, June 11, 2014 /PRNewswire-iReach/ -- Resolve Herpes, a company that offers all-natural mineral formulations, has just announced the launch of a new and effective herpes treatment. Called ResolveHerpes, the product is designed to help boost the body's immune system, which in turn can help it naturally clear out the herpes viruses HSV-1 and HSV-2.

Photo - http://photos.prnewswire.com/prnh/20140611/117174

As anyone who has dealt with the often-painful and embarrassing herpes symptoms knows quite well, it can be a very difficult condition to treat. While topical creams and drugs can make people feel better for a short time, they do not help to remove the virus from the body. During an outbreak, creams and antiviral drugs like Valtrex, Famivir and Acyclovir will help relieve the itching and burning and other symptoms, but the contained virus inside the person's cells will continue to multiply.

Through an innovative two-step process, ResolveHerpes goes well beyond simply putting a figurative band-aid over a herpes outbreak and goes deep into the body where the herpes simplex virus is living and multiplying. The formula, which some customers have called the "herpes solution," allows the body to effectively eliminate the viruses, fungi and toxins from the cells.

During Step One, which takes 36 days, people slowly increase their dosage of ResolveHerpes to 20 mls, 3 times a day. As the minerals push the virus out from the cells, people often experience minor symptoms such as pimples and a runny nose. This is actually proof that the mineral supplement is working and is nothing to be concerned about.

"The final part of the detox consists of concentrated minerals that are taken three times a day for 14 days," a spokesperson for ResolveHerpes noted, adding that this final part of the detox has the effect of allowing the body to expel any free viruses that remain in the body.

People who would like to learn more about ResolveHerpes are welcome to visit the company's website; there, they can read in-depth articles about the product and why it is so effective. The website also features a variety of positive customer testimonials from people who have had great success using the product.

"Last year I returned positive for Herpes types 1 and 2," wrote a customer named Brett, who said he then took the ResolveHerpes formula.

"I have just received the results for the exact same STD screen that I took last year, and the results for both Herpes type 1 and type 2 have come back negative. The test now states there is no evidence of myself ever being exposed to HSV."

About Resolve Herpes:

Resolve Herpes is a small, innovative company that is fortunate to have the benefit of a hardworking, inventive, and ingenious practitioner who for over 20 years refined a combination of all-natural and supremely pure minerals that could infiltrate every cell in the body and allow the body itself to do what it was naturally designed to do -- rid itself of most types of harmful toxins and viruses. The company features a product called ResolveHerpes that can help push toxins and viruses out of the body. For more information, please visit http://www.resolveherpes.com/

Media Contact: Customer Support, Resolve Herpes, (760) 742-5190, info@resolveherpes.com

News distributed by PR Newswire iReach: https://ireach.prnewswire.com

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Rihanna Herpes and Lipstick Fiasco Shows Need for Effective Herpes Remedy; polyDNA Recommends Gene-Eden-VIR to Kill ...

Rochester, NY (PRWEB) June 11, 2013

The National Health Service website says that “It is not possible to prevent becoming infected with the herpes simplex virus or to prevent outbreaks of cold sores.” (1) In fact, there are many ways that oral herpes (HSV-1) can be transmitted. Even a shared tube of lipstick can be a method of herpes transmission. (2) That’s why people need a remedy that can help their immune system kill the virus once it enters the body.

For example, 28 year old Starkeema Greenridge of Harlem could have used such a remedy when she “was infected by the virus when she sampled a lipstick offered by one of the singer's sponsors.”(The Guardian, May 31, 2013) (3)

"If a woman has a cut on her lip and borrows lipstick from someone who has a cold sore, she'll get a cold sore. You can pass herpes [the cold sore virus], conjunctivitis [pink eye] and all sorts of things through sharing makeup," - Dr. Zein Obagi (Los Angeles Times, 2010) (4)

Another doctor noted that “direct contact with a herpes lesion, engaging in sexual activity with an actively infected person or sharing a drinking glass, lipstick or cigarette with a person with an active herpes outbreak on their mouth could transmit the disease.” (Dr. Joy M. Jackson, Healthtap.com) (5)

“Since oral herpes spreads so easily, people need protection. I recommends Gene-Eden-VIR.” – Mike Evans, polyDNA

Gene-Eden-VIR is a natural dietary supplement that helps the immune system kill the herpes virus. polyDNA recommends that people who want to protect themselves against the herpes virus or are already infected take Gene-Eden-VIR.

Gene-Eden-VIR is designed to fight the latent herpes virus. A recent post marketing clinical study showed that Gene-Eden-VIR is safe and effective. Up to 70% of those studied reported a decrease in herpes symptoms. (6)

Each ingredient of Gene-Eden-VIR was chosen through a scientific approach. Scientists scanned thousands of scientific and medical papers published in various medical and scientific journals around the world to identify the safest, most effective natural ingredients that target the latent form of herpes. (7)

To learn more about Gene-Eden-VIR, visit http://www.gene-eden-kill-virus.com. All orders of Gene-Eden-VIR are completely confidential, and no information is shared or sold to any third party. Privacy is assured.

References:

(1)    http://articles.latimes.com/2010/apr/18/image/la-ig-testers-20100418
(2)    http://www.nhs.uk/Conditions/Cold-sore/Pages/Prevention.aspx
(3)    http://www.guardian.co.uk/music/2013/may/31/rihanna-lipstick-gave-me-herpes
(4)    http://articles.latimes.com/2010/apr/18/image/la-ig-testers-20100418
(5)    https://www.healthtap.com/topics/can-you-get-herpes-from-sharing-lipstick
(6)    cbcd.net/Gene-Eden-VIR-Clinical-Study.php
(7)    gene-eden-kill-virus.com/studies.php

polyDNA is a biotechnology company that develops dietary supplements using the unique scientific method developed by Dr. Hanan Polansky, which is based on Computer Intuition.

In addition to his unique scientific method, Dr. Polansky published the highly acclaimed scientific discovery, called Microcompetition with Foreign DNA. The discovery explains how foreign DNA fragments, and specifically, DNA of latent viruses, cause most major diseases.

polyDNA developed Gene-Eden-VIR , an antiviral natural remedy that helps the immune system kill latent viruses.

View the original article here

Oral Herpes Laser Treatment Effective Yet Expensive According to New Review; polyDNA recommends Gene-Eden-VIR, an ...

Rochester, NY (PRWEB) June 24, 2013

Recently, laser treatment has been used for the treatment of oral herpes. Scientific literature shows that this new treatment appears to be safe and effective. Yet, a new review published in April 2013 in the journal Lasers in Medical Science shows that there are two drawbacks to this method of therapy.(2)

The first is that although it appears to be safe and effective, there is no definite proof. As the review noted, “The main advantages of laser treatment appear to be the absence of side effects and drug interactions…The literature still lacks double-blind controlled clinical trials verifying these effects…..” (2)

The second is that it is prohibitively expensive. According to Realself.com, the national average for a series of laser treatments ranges from a few hundred dollars to well over two thousand dollars. (1)

polyDNA urges the scientific community to conduct more clinical trials of this promising technology. As well, polyDNA hopes that the price will come down as the technology improves. In the meantime, polyDNA recommends Gene-Eden-VIR, an effective and affordable alternative.

“Laser therapy for the relief of oral herpes symptoms sounds like a great idea. The literature shows some real promise. But, who can afford hundreds of dollars for removing cold sores? People need an oral herpes remedy that works, and that is affordable.” – Mike Evans, polyDNA

polyDNA recommends Gene-Eden-VIR to individuals with an oral herpes infection. Gene-Eden-VIR boosts the immune system and helps it attack and eliminate the latent herpes virus. A 2012 post marketing clinical study showed that Gene-Eden-VIR is safe and effective. Up to 70% of those studied reported a decrease in viral symptoms. (3)

In some cases, Gene-Eden-VIR produces complete immunity. This means that it boosts the immune system to 100% efficiency, and helps the body eliminate (or clear) all viruses of a specific type, specifically, those in the home base, or the latent viruses. When the person is clear of all the latent viruses, that person is said to be 'cured'. There are no viruses left and no symptoms.

However, sometimes, Gene-Eden-VIR does not boost the immune system back to 100% efficiency. In these cases, some viruses still remain in the body. If the immune system is strong enough to hold the foreign forces within their home base, there are no scrimmages, that is, no symptoms and no disease. When this happens, this person is not cured, but he experiences a long term remission.

Each ingredient of Gene-Eden-VIR was chosen through a scientific approach. Scientists scanned thousands of scientific and medical papers published in various medical and scientific journals around the world to identify the safest, most effective natural ingredients that target the latent form of herpes. (4)

To learn more about Gene-Eden-VIR and herpes, visit http://www.gene-eden-kill-virus.com/Herpes-Remedy.php. All orders of Gene-Eden-VIR are completely confidential, and no information is shared or sold to any third party. Privacy is assured.

Reference:

(1) http://www.realself.com/laser-treatment/cost
(2) http://link.springer.com/article/10.1007%2Fs10103-013-1311-8/fulltext.html
(3) http://www.cbcd.net/Gene-Eden-VIR-Clinical-Study.php
(4) http://gene-eden-kill-virus.com/studies.php

polyDNA is a biotechnology company that develops dietary supplements using the unique scientific method developed by Dr. Hanan Polansky, which is based on Computer Intuition.

In addition to his unique scientific method, Dr. Polansky published the highly acclaimed scientific discovery, called Microcompetition with Foreign DNA. The discovery explains how foreign DNA fragments, and specifically, DNA of latent viruses, cause most major diseases.

polyDNA developed Gene-Eden-VIR , an antiviral natural remedy that helps the immune system kill latent viruses.

View the original article here

Herpes Cure that is Effective and Safe is the Focus of New EBook Available at HerpesEliminator.com

The EBook, Which was Written by a Former Herpes Sufferer, Contains In-Depth and Helpful Information about a Product that Claims to Help Get Rid of Herpes

London, UK (PRWEB) April 16, 2013

HerpesEliminator.com, a website that is devoted to helping people get rid of herpes, has just launched a new Ebook that provides readers with in-depth information about a herpes cure that is allegedly extremely effective.

The Ebook was written by a young woman named Emily Sheela. Like millions of other people, Emily was devastated when she was diagnosed with herpes. For almost four years, Emily tried every herpes remedy her doctor recommended, including powerful anti-viral medications that made her feel ill and ultimately did not work.

Desperate to find a herpes treatment that would help her find relief, Emily began to read all she could about the disease and the natural remedies that could help get rid of herpes. Through her research, Emily discovered a product called Herpes Eliminator that offers an all-natural, organic method that not only relieves the symptoms of the disease, but may actually cure herpes. Emily began to use the product, and almost immediately noticed that she was feeling much better. Her troublesome symptoms began to abate, and—unlike the medication she had been taking—Herpes Eliminator didn’t cause any negative side effects.

Emily’s extremely positive experience with Herpes Eliminator inspired her to show others how to get rid of herpes. She transformed it into a formalized product and wrote an Ebook about it, which is now available through the HerpesEliminator.com website.

On the website, Emily also discusses her very personal experience with herpes through a series of articles. She hopes by sharing her story of triumph over herpes, that other people will feel empowered to try the product and experience the same level of success and good health.

“Herpes Eliminator works quickly to reduce and eliminate unsightly genital sores caused by the Herpes Type 2 virus along with other types of herpes and even eliminates the virus from your body forever and it works for both men and women,” Emily wrote in an article on her website, adding that the product, which is based on thousands of years of Eastern medicine, can be an effective self-treatment process.

Anybody who would like to learn more about Herpes Eliminator is welcome to visit the website at any time; there, they can read Emily’s story and information about the natural product that can finally rid people of herpes once and for all. Those who wish to purchase the Ebook may do so safely and securely through the site.

About HerpesEliminator.com:

HerpesEliminator.com is a website that is devoted to helping people eliminate their herpes through a safe and natural product called Herpes Eliminator. The site, which was founded by Emily Sheela, a previous herpes sufferer, includes in-depth articles about her experience as well as an Ebook that explains how Herpes Eliminator helped Emily rid herself of herpes. For more information, please visit http://herpeseliminator.com

View the original article here

Herpes Remedy, Gene-Eden-VIR, Can Be Effective Against Herpes Related Memory Problems

1 out of 4 women infected with the herpes virus suffer from memory problems. polyDNA’s herpes remedy, Gene-Eden-VIR, helps immune system kill HSV-1, and therefore may be effective in treating memory problems.

Rochester, NY (PRWEB) April 01, 2013

polyDNA researchers have linked the ingredients of Gene-Eden-VIR, an all natural, scientific herpes remedy, with an improvement of cognitive functions. While conducting research into herpes related illnesses, polyDNA found that women with a herpes type 1 infection have a significantly higher risk of developing memory problems and other cognitive issues. [1]

This is even more noteworthy since “60 percent of U.S. men and women between the ages of 14 and 49 carry the herpes simplex type 1 virus.” [2]

Cinnamon is a natural antiviral. [3] Moreover, cinnamon has also been found to naturally boost memory and other cognitive functions by inhibiting tau aggregation and filament formation, which are hallmarks of Alzheimer's disease (AD). [4]

Gene-Eden-VIR’s all natural ingredients include cinnamon. In fact, Gene-Eden-VIR contains five all natural antiviral ingredients including cinnamon, selenium, quercetin, and licorice extract.

Mike Evans from polyDNA said “The fact that nature has given us an all natural ingredient that has scientifically been shown to combat both herpes as well as prevent other cognitive problems is amazing. It’s even more amazing since herpes can also cause brain problems. When we developed Gene-Eden-VIR, we knew we wanted it to be a natural remedy with as broad an application as possible. This research shows exactly how Gene Eden can take on two seemingly unrelated illnesses, focus on the source of those illnesses, and then work to combat those illnesses’ origin.”

The public should be aware of the relationship between herpes and cognitive problems and take steps to prevent those problems from arising. polyDNA recommends boosting the immune system against a latent herpes infection through the use the all natural herpes remedy, Gene-Eden-VIR.

A recent post marketing clinical study showed that Gene-Eden-VIR is effective against the latent herpes virus. By helping the body's immune system target the latent herpes virus, people also lower their risk of developing fever blisters, cold sores, or genital herpes symptoms. [5]

Gene-Eden-VIR is highly effective against the latent herpes virus, each ingredient was chosen through a scientific approach. Scientists scanned thousands of scientific and medical papers published in various medical and scientific journals around the world to identify the safest, most effective natural ingredients that target the latent forms of both HSV-1 and HSV-2. [6]

To learn more about Gene-Eden-VIR, visit http://www.gene-eden-kill-virus.com.

References:

1: Infectious burden and cognitive function

2: For Many, Herpes May Cause Memory Loss Along with Cold Sores

3 : In vitro and in vivo activity of eugenol on human herpesvirus

4 : Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro

5 : Gene-Eden-VIR is Antiviral: Results of a Post Marketing Clinical Study

6 : The antiviral effect of Gene-Eden

polyDNA is a biotechnology company that develops dietary supplements using the unique scientific method developed by Dr. Hanan Polansky, which is based on Computer Intuition.

In addition to his unique scientific method, Dr. Polansky published the highly acclaimed scientific discovery, called Microcompetition with Foreign DNA. The discovery explains how foreign DNA fragments, and specifically, DNA of latent viruses, cause most major diseases.

polyDNA developed Gene-Eden-VIR , an antiviral natural remedy that helps the immune system kill latent viruses.

Mike Davis
PolyDNA
5852509999
Email Information

View the original article here

New Study: Herpes Remedy, Gene-Eden-VIR, Can Be Effective in Speeding Up Cold Sore Healing Time

In a new study, polyDNA’s antiviral herpes remedy, Gene-Eden-VIR worked to speed healing time of herpes cold sores with over 73% percent of the individuals treated reporting a decrease in their symptoms. [1]

Rochester, NY (PRWEB) April 05, 2013

A new study by researchers at the Center for the Biology of Chronic Disease (CBCD) shows that Gene-Eden-VIR, an all natural, herpes remedy is effective against HSV-1.

This is significant since, “Herpes simplex virus type-1 (HSV-1) is a condition affecting nearly 40% of the US population.” [2] Due to the results of this new study, polyDNA recommends Gene-Eden-VIR against the virus that causes cold sores.

Infected individuals should consider Gene-Eden-VIR since “Prescription drugs are only effective if begun very early, and reduce healing time by 1 to 2 days.” [3]

In fact, these prescription drugs have several drawbacks including:

In contrast, Gene-Eden-VIR is sold online without the need for a doctor’s visit or a prescription. In multiple studies its ingredients were found to be effective against the herpes virus, [5] In addition, this herpes remedy was found to be safe with no side effects and with a significant decrease in the frequency and duration of symptoms. [1]

Gene-Eden-VIR’s ingredients include a patent protected, unique formula of selenium, Camellia Sinesis extract, quercetin, cinnamomum extract, and licorice extract. In addition each bottle is GMP certified.

To learn more about how Gene-Eden-VIR can speed up healing of cold sores, visit http://www.gene-eden-kill-virus.com.

References:

[1] [2 Snoeck R, De Clercq E. Treatment of herpes simplex virus infections. Infect Med. 1999;16(4):249–65.

[3] Esmann J. The many challenges of facial herpes simplex virus infection. J Antimicrob Chemother.2001;47:17–27.

[4] [5 http://www.gene-eden-kill-virus.com/studies.php

###

polyDNA is a biotechnology company that develops dietary supplements using the unique scientific method developed by Dr. Hanan Polansky, which is based on Computer Intuition.

In addition to his unique scientific method, Dr. Polansky published the highly acclaimed scientific discovery, called Microcompetition with Foreign DNA. The discovery explains how foreign DNA fragments, and specifically, DNA of latent viruses, cause most major diseases.

polyDNA developed Gene-Eden-VIR , an antiviral natural remedy that helps the immune system kill latent viruses.

Mike Davis
PolyDNA
5852509999
Email Information

View the original article here

New way to target viruses could make antiviral drugs more effective

ScienceDaily (July 21, 2010) — Scientists have developed a new way to target viruses which could increase the effectiveness of antiviral drugs.

Instead of attacking the virus itself, the method developed at the University of Edinburgh alters the conditions which viruses need to survive and multiply.

By making the site of infection less hospitable for the virus, the virus becomes less able to mutate and build up resistance to drugs. The researchers were also able to target more than one virus at the same time.

Viruses take up residence in host cells within our body, which produce proteins that enable the virus to multiply and survive.

The study, published in the journal Proceedings of the National Academy of Sciences (PNAS), analysed molecules known as microRNAs, which regulate how much of these proteins are made.

The scientists were able to manipulate the microRNA levels, which enabled them to control a network of proteins and stop viruses from growing.

Most existing antiviral therapies only work against one virus. However, by adapting the virus host environment the researchers were able to target different types of viruses.

It is hoped that the research could lead to new treatments for patients suffering from a range of infections.

Dr Amy Buck, of the University's Centre for Immunity, Infection & Evolution, said: "A problem with current antiviral therapies, which generally target the virus, is that viruses can mutate to become resistant. Since new viral strains emerge frequently, and many infections are difficult to diagnose and treat, it is important to find new ways of targeting infection. Our hope is that we will be able to use host-directed therapies to supplement the natural immune response and disable viruses by taking away what they need to survive."

Scientists studied the herpes family of viruses, which can also cause cancer with the Epstein-Barr virus, and the Semliki Forest virus, which is mainly spread by mosquitoes.

Both viruses have different characteristics. Viruses from the herpes family replicate inside the nuclei of cells, while the Semliki Forest multiplies outside the nucleus of a cell.

Further research has begun to look at how this method could be used to target influenza.

The study was funded by the Wellcome Trust and the Biotechnology and Biological Sciences Research Council.

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Story Source:

The above story is reprinted from materials provided by University of Edinburgh.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Diwakar Santhakumar, Thorsten Forster, Nouf N. Laqtom, Rennos Fragkoudis, Paul Dickinson, Cei Abreu-Goodger, Sergei A. Manakov, Nila Roy Choudhury, Samantha J. Griffiths, Annaleen Vermeulen, Anton J. Enright, Bernadette Dutia, Alain Kohl, Peter Ghazal, and Amy H. Buck. Combined agonist-antagonist genome-wide functional screening identifies broadly active antiviral microRNAs. Proceedings of the National Academy of Sciences, 2010; DOI: 10.1073/pnas.1008861107

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

View the original article here

Drug against AIDS could be effective against herpesvirus

ScienceDaily (Sep. 24, 2010) — Scientists at the Institute for Research in Biomedicine (IRB Barcelona) headed by the coordinator of the Structural and Computational Biology Programme, Miquel Coll, have published a new study that demonstrates that raltegravir, the drug approved in 2007 for the treatment of AIDS that is sold by Merck under the name Isentress, cancels the function of an essential protein for the replication of one kind of herpes virus. This study, published in the journal Proceedings of the National Academies of Sciences (PNAS), is the first step towards the development of a drug against the entire herpesvirus family.

"These results have a clear medical impact for three reasons," explains Miquel Coll, also a CSIC research professor. "First, humans do not have the viral protein that is affected, thus this would allow a highly specific drug that does not show the secondary effects that other drugs may have. Second, the inhibitor is not toxic for humans when administered at therapeutic concentrations because it is already on the market and thus toxicity tests are facilitated; and third, we have data that indicate that all herpes viruses have this protein. Therefore, it could be a valid target against all Herpesviridae."

Herpesviruses include pathogens such as herpes simplex 1 and 2, the virus that causes chickenpox otherwise known as zoster virus, the Epstein-Barr virus -associated with several types of cancer -, the roseola virus, the cytomegalovirus and the herpes virus associated with Kaposi sarcoma -in AIDS patients -. The human cytomegalovirus (HCMV), on which the study was performed, causes neurological defects in 1% of neonates in developed countries. It also produces retinitis that deteriorates into blindness in 25% of subjects with AIDS, defects in the brains and central nervous systems of young adults, inflammation of the colon -also in those with AIDS -, mononucleosis and serious diseases of the throat. Although 90% of adults carry HCMV, this virus is opportunistic, acting in people with weakened immune systems such as in cancer and AIDS patients, recipients of organ transplants and neonates.

Blocking viral replication

To replicate, the herpes virus enters the nucleus of a cell where it uses the cell machinery to copy its DNA several times into a single large chain. Once this copy has been made, acts a complex called terminase, formed by three protein subunits. The terminase cuts the new DNA into small fragments, the size of a single viral genome, and introduces these into empty shells (capsids) that have developed in the cell nucleus. Then, the new viruses leave the cell to continue infection. The researchers resolved the 3D structure of one part of the terminase and when they observed that it resembled the integrase of the AIDS virus, for which drugs are available, they tested it against the herpes virus protein. Thus they discovered that raltegravir acts on the subunit UL89 of the terminase and cancels the scissor function, which is required for viral replication.

The assays were performed directly on the protein in test tubes. "Now we must do the assays on whole infected cells, improve the effect of the drug and validate that it is also effective for other kinds of herpes viruses," explains Miquel Coll, whose lab has patented this second application for raltegravir. To resolve the 3D structure of the target protein, the scientists have used a state-of-the-art high-performance protein expression technique, with the collaboration with Darren Hart's group at EMBL in Grenoble, where 18,000 clones or different fragments of the protein have been tested. They have also used the Grenoble synchrotron to obtain the structural data. The study has lasted five years and forms part of the European project SPINE-2 complexes.

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Story Source:

The above story is reprinted from materials provided by Institute for Research in Biomedicine-IRB.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

M. Nadal, P. J. Mas, A. G. Blanco, C. Arnan, M. Sola, D. J. Hart, M. Coll. Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain. Proceedings of the National Academy of Sciences, 2010; 107 (37): 16078 DOI: 10.1073/pnas.1007144107

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

View the original article here

Drug against AIDS could be effective against herpesvirus

ScienceDaily (Sep. 23, 2010) — Scientists at the Institute for Research in Biomedicine (IRB Barcelona) headed by the coordinator of the Structural and Computational Biology Programme, Miquel Coll, have published a new study that demonstrates that raltegravir, the drug approved in 2007 for the treatment of AIDS that is sold by Merck under the name Isentress, cancels the function of an essential protein for the replication of one kind of herpes virus. This study, published in the journal Proceedings of the National Academies of Sciences (PNAS), is the first step towards the development of a drug against the entire herpesvirus family.

"These results have a clear medical impact for three reasons," explains Miquel Coll, also a CSIC research professor. "First, humans do not have the viral protein that is affected, thus this would allow a highly specific drug that does not show the secondary effects that other drugs may have. Second, the inhibitor is not toxic for humans when administered at therapeutic concentrations because it is already on the market and thus toxicity tests are facilitated; and third, we have data that indicate that all herpes viruses have this protein. Therefore, it could be a valid target against all Herpesviridae."

Herpesviruses include pathogens such as herpes simplex 1 and 2, the virus that causes chickenpox otherwise known as zoster virus, the Epstein-Barr virus -associated with several types of cancer -, the roseola virus, the cytomegalovirus and the herpes virus associated with Kaposi sarcoma -in AIDS patients -. The human cytomegalovirus (HCMV), on which the study was performed, causes neurological defects in 1% of neonates in developed countries. It also produces retinitis that deteriorates into blindness in 25% of subjects with AIDS, defects in the brains and central nervous systems of young adults, inflammation of the colon -also in those with AIDS -, mononucleosis and serious diseases of the throat. Although 90% of adults carry HCMV, this virus is opportunistic, acting in people with weakened immune systems such as in cancer and AIDS patients, recipients of organ transplants and neonates.

Blocking viral replication

To replicate, the herpes virus enters the nucleus of a cell where it uses the cell machinery to copy its DNA several times into a single large chain. Once this copy has been made, acts a complex called terminase, formed by three protein subunits. The terminase cuts the new DNA into small fragments, the size of a single viral genome, and introduces these into empty shells (capsids) that have developed in the cell nucleus. Then, the new viruses leave the cell to continue infection. The researchers resolved the 3D structure of one part of the terminase and when they observed that it resembled the integrase of the AIDS virus, for which drugs are available, they tested it against the herpes virus protein. Thus they discovered that raltegravir acts on the subunit UL89 of the terminase and cancels the scissor function, which is required for viral replication.

The assays were performed directly on the protein in test tubes. "Now we must do the assays on whole infected cells, improve the effect of the drug and validate that it is also effective for other kinds of herpes viruses," explains Miquel Coll, whose lab has patented this second application for raltegravir. To resolve the 3D structure of the target protein, the scientists have used a state-of-the-art high-performance protein expression technique, with the collaboration with Darren Hart's group at EMBL in Grenoble, where 18,000 clones or different fragments of the protein have been tested. They have also used the Grenoble synchrotron to obtain the structural data. The study has lasted five years and forms part of the European project SPINE-2 complexes.

Share this story on Facebook, Twitter, and Google:

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Story Source:

The above story is reprinted from materials provided by Institute for Research in Biomedicine-IRB, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

M. Nadal, P. J. Mas, A. G. Blanco, C. Arnan, M. Sola, D. J. Hart, M. Coll. Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain. Proceedings of the National Academy of Sciences, 2010; 107 (37): 16078 DOI: 10.1073/pnas.1007144107

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

View the original article here

Zostavax - An Effective Vaccine to Prevent Shingles

Shingles or Herpes Zoster is a disease which people over the age of 60 or having prolonged illnesses will be painfully aware of. The usual symptom is a very painful rash which usually develops on one side of the body along the nerves that carry the Herpes Zoster virus.

Herpes Zoster originates from the Herpes virus, which is the cause of the common childhood disease chickenpox. After a bout of chickenpox, the Herpes virus still remains in a child's body albeit in a dormant state. However as age progresses and as the immunity system becomes weaker and weaker, the Herpes Zoster virus might overcome the immunity system and cause shingles. This is the most common reason as to why shingles is prevalent in adults over 60 or having prolonged illnesses that tend to waken their immunity.

The Herpes vaccine has been approved only recently by the Food and Drug Administration (FDA) to prevent the occurrence of shingles in adults over 60. This vaccine, named Zostavax, was developed by pharmaceutical company Merck and it has existed as a marketable drug since May 2006 after the FDA approved it.

Zostavax prevent the older population, who already carry the latent Herpes Zoster virus, from being infected by shingles. However, this vaccine is only effective when it is administered before the illness. It cannot heal shingles once it is contracted, only prevent it. Zostavax is also effective in preventing the contraction of post-hermetic neuralgia.

This vaccine is actually a weakened form of varicella zoster virus, which is generally obtained from children who have this virus occurring naturally in their bodies. This virus has been tested at the Merck laboratory and it has been found out that it possesses no harmful substances.

Tests have been done to prove the effectiveness of the Zostavax vaccine. Over 20,000 adults over 60 were tested in a double blind test where they were provided with placebos and Zostavax. It was found out that the Herpes vaccine prevented the contraction of shingles and post neuralgia in more than half of the people tested, who had been infected by these viruses. The most positive result was found to be in the age group between 60 and 69 though this vaccine showed some positive effects in all age groups.

Like most of the drugs, this too is not without side effects. However, these side effects are minimal. The most common side effects are itchiness, pain, swelling etc. in the region where the vaccine is injected. But these side effect are temporary and therefore not a cause of worry.

Headache is another side effect in addition to inflammation in the injected area. But these headaches have occurred in less than 2 percent of the people who have been injected with this vaccine. There might be a very rare chance of emergence of the varicella zoster virus, although no such emergence has been reported till date.

Overall, Zostavax is an effective vaccine against shingles. However, it is best to consult a physician or a doctor about its usage.

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Herpes Virus Effective in Treating Triple Negative Breast Cancer - Med India

Moreover, Dr. Gholami explained that TNBC cells have high levels of p-MAPK, a protein that promotes cancer cells to grow and has been reported as a potential cause for resistance to current conventional therapies. Knowing that the herpes virus specifically targets cells that over express this protein is the reason she chose to test this treatment protocol. "When we infect TNBC cells with the herpes virus and measure p-MAPK levels, the protein level decreases with time after treatment with the virus," Dr. Gholami said.

The hope is that advances in oncolytic viral therapy, which uses viruses tailored to target and destroy cancer cells while sparing healthy cells, will allow researchers to develop more effective strategies for hard-to-treat cancers. A similar herpes virus has been tested in clinical trials against head and neck cancers. But this is the first laboratory study to show promise in using the therapy to treat TNBC.

The next steps, Dr. Gholami said, are to map out the pathways in which the virus kills the tumor cells to determine how to improve upon this mechanism. In the future, the Fong laboratory, which is on the forefront in oncolytic viral therapy research, will continue this avenue of investigation in animal studies. The team will also work to identify leads to understand what existing chemotherapy drugs can be used synergistically with this viral therapy. Finding complementary treatments that kill fast-growing cancer cells and combat resistance is the key to possibly making a cure a reality.

If additional animal studies are also positive, human clinical trials could be on the horizon. "Our goal is to improve this version of the virus and get it into a clinical trial," Dr. Gholami said. "Ultimately, I believe the treatment for TNBC will be a multimodality targeted treatment approach: potentially using a viral-based therapy plus some other targeted chemotherapy or radiation."

The study was supported by grants from the National Institutes of Health and the Flight Attendant Medical Research Institution.

Source-Newswise

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