Herpes Simplex Infections (Cold Sores, Non-Genital)

MedWorm: Genital Herpes Herpes Simplex Infections (Cold Sores, Non-Genital) March 24, 2011 at 2:00 AM Title: Herpes Simplex Infections (Cold Sores, Non-Genital)Category: Diseases and ConditionsCreated: 6/16/1999 7:38:00 PMLast Editorial Review: 3/24/2011 (Source: MedicineNet Hearing General) MedWorm Sponsor Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!

Health-related quality of life in Indian patients with three viral sexually transmitted infections: herpes simplex virus-2, genital human papilloma virus and HIV

MedWorm: Genital Herpes Health-related quality of life in Indian patients with three viral sexually transmitted infections: herpes simplex virus-2, genital human papilloma virus and HIV March 20, 2011 at 7:00 PM Conclusion Viral STIs were associated with a significant reduction in HRQOL scores. Among patient groups, the greatest impact on HRQOL was seen in those with HIV and mixed infections and the least impact seen in those with genital HPV infection. Comprehensive care including counselling services need to be implemented in STI clinics. (Source: Sexually Transmitted Infections) MedWorm Sponsor Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!

A Live-Attenuated HSV-2 ICP0 Virus Elicits 10 to 100 Times Greater Protection against Genital Herpes than a Glycoprotein D Subunit Vaccine.

MedWorm: Genital Herpes Viral Linkage in HIV-1 Seroconverters and Their Partners in an HIV-1 Prevention Clinical Trial. March 19, 2011 at 3:00 AM CONCLUSIONS/SIGNIFICANCE: In this first use of HIV-1 sequencing to establish endpoints in a large clinical trial, more than one-fourth of transmissions were unlinked to the enrolled partner, illustrating the relevance of these methods in the design of future HIV-1 prevention trials in serodiscordant couples. A hierarchy of sequencing techniques, analysis methods, and expert adjudication contributed to the linkage determination process. PMID: 21399681 [PubMed - as supplied by publisher] (Source: Herpes) A Live-Attenuated HSV-2 ICP0 Virus Elicits 10 to 100 Times Greater Protection against Genital Herpes than a Glycoprotein D Subunit Vaccine. March 19, 2011 at 3:00 AM Authors: Halford WP, Püschel R, Gershburg E, Wilber A, Gershburg S, Rakowski B Glycoprotein D (gD-2) is the entry receptor of herpes simplex virus 2 (HSV-2), and is the immunogen in the pharmaceutical industry's lead HSV-2 vaccine candidate. Efforts to prevent genital herpes using gD-2 subunit vaccines have been ongoing for 20 years at a cost in excess of $100 million. To date, gD-2 vaccines have yielded equivocal protection in clinical trials. Therefore, using a small animal model, we sought to determine if a live-attenuated HSV-2 ICP0(-) virus would elicit better protection against genital herpes than a gD-2 subunit vaccine. Mice immunized with gD-2 and a potent adjuvant (alum+monophosphoryl lipid A) produced high titers of gD-2 antibody. While gD-2-immunized mice possessed signific... MedWorm Sponsor Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily! Correlates of HIV-1 Genital Shedding in Tanzanian Women. March 19, 2011 at 3:00 AM We examined correlates of genital HIV-1 RNA in women who were seropositive for both herpes simplex virus (HSV)-2 and HIV-1 and who were enrolled in a randomised controlled trial of HSV suppressive therapy (aciclovir 400 mg b.i.d vs. placebo) in Tanzania. PMID: 21390251 [PubMed - in process] (Source: Herpes)